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Ionis Pharmaceuticals, Inc.$45.19($1.16)(2.50%)

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From 7/27/2018 to 10/19/2018 
Date Open High Low Close Volume
10/19/2018 46.410 47.480 44.670 45.190 837,500
10/18/2018 47.460 47.460 45.410 46.350 534,600
10/17/2018 47.270 47.690 46.330 47.340 708,900
10/16/2018 45.370 47.540 44.720 47.490 873,600
10/15/2018 45.070 45.820 44.520 45.130 749,900
10/12/2018 44.190 45.600 44.030 45.000 911,700
10/11/2018 44.060 45.450 43.270 43.370 1,343,000
10/10/2018 46.500 46.500 44.000 44.060 1,460,600
10/9/2018 44.750 46.570 44.530 44.890 1,650,900
10/8/2018 47.000 47.280 44.160 45.000 3,512,200
10/5/2018 47.340 49.300 46.860 48.730 818,800
10/4/2018 47.970 47.970 46.560 47.480 1,202,800
10/3/2018 48.690 48.890 47.480 47.990 1,372,600
10/2/2018 50.090 50.490 48.020 48.550 1,094,000
10/1/2018 51.940 52.010 49.870 50.060 865,000
9/28/2018 51.800 52.400 51.260 51.580 942,700
9/27/2018 51.140 52.610 51.000 51.730 718,600
9/26/2018 51.710 52.240 50.570 51.390 864,600
9/25/2018 50.520 52.130 50.220 51.520 2,152,300
9/24/2018 49.080 51.220 49.000 50.510 1,002,900
9/21/2018 50.830 50.980 48.780 49.140 1,728,000
9/20/2018 50.000 51.050 49.570 50.800 701,900
9/19/2018 49.300 50.200 49.000 49.980 653,400
9/18/2018 48.170 50.150 48.170 49.360 1,481,300
9/17/2018 46.110 48.240 46.110 48.190 1,762,000
9/14/2018 45.080 46.110 45.040 46.000 844,900
9/13/2018 45.360 46.100 44.730 45.090 964,800
9/12/2018 44.790 45.340 43.870 45.040 869,200
9/11/2018 44.500 45.280 44.100 44.650 630,600
9/10/2018 44.100 44.890 43.750 44.550 933,000
9/7/2018 44.220 45.180 43.860 44.180 775,400
9/6/2018 44.930 45.390 43.810 44.460 1,020,400
9/5/2018 45.760 46.110 44.930 45.060 876,100
9/4/2018 45.410 45.800 44.575 45.760 1,448,200
8/31/2018 46.180 46.940 45.560 45.690 556,800
8/30/2018 46.190 46.750 45.840 46.430 908,300
8/29/2018 45.170 47.170 45.170 46.190 1,816,900
8/28/2018 47.000 48.250 45.000 45.170 6,119,100
8/27/2018 50.160 54.850 49.920 53.700 2,671,800
8/24/2018 51.580 51.920 49.310 49.800 2,031,300
8/23/2018 52.510 52.590 51.020 51.210 1,199,700
8/22/2018 53.310 53.480 52.670 52.680 1,030,500
8/21/2018 51.880 53.765 51.880 53.250 1,048,000
8/20/2018 50.650 52.120 50.325 51.670 830,700
8/17/2018 51.250 51.250 50.310 50.840 712,600
8/16/2018 50.060 51.790 49.210 51.420 794,900
8/15/2018 50.720 50.920 49.110 49.650 960,300
8/14/2018 50.050 51.530 49.790 51.020 1,065,600
8/13/2018 48.880 50.150 48.200 50.010 1,226,600
8/10/2018 47.770 51.640 47.770 48.700 2,341,500
8/9/2018 45.390 48.600 44.780 48.210 1,239,700
8/8/2018 43.360 45.900 43.300 45.570 1,543,100
8/7/2018 43.000 44.240 41.250 44.200 1,407,300
8/6/2018 43.880 44.500 43.110 43.650 600,800
8/3/2018 44.640 44.640 43.610 43.620 524,000
8/2/2018 42.970 44.450 42.500 44.440 691,900
8/1/2018 43.230 44.020 42.500 43.090 719,400
7/31/2018 43.840 44.590 43.580 43.680 932,800
7/30/2018 44.720 44.720 43.360 43.690 741,500
7/27/2018 46.000 46.100 44.420 45.040 793,200


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