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Ionis Pharmaceuticals, Inc.$44.85($.38)(.84%)

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From 3/1/2018 to 5/25/2018 
Date Open High Low Close Volume
5/25/2018 45.030 45.160 44.220 44.850 515,000
5/24/2018 44.090 45.740 43.750 45.230 709,800
5/23/2018 43.080 44.550 42.740 44.090 536,500
5/22/2018 43.330 44.280 43.080 43.800 596,800
5/21/2018 45.000 45.290 42.955 43.230 777,900
5/18/2018 43.760 44.710 43.510 44.640 1,117,900
5/17/2018 43.730 44.125 43.150 43.830 1,079,700
5/16/2018 44.510 44.870 43.400 43.710 1,184,500
5/15/2018 45.830 46.130 44.260 44.390 1,141,800
5/14/2018 46.000 47.450 45.540 46.380 1,496,200
5/11/2018 43.030 46.000 43.000 45.950 1,619,300
5/9/2018 40.660 43.100 40.620 42.800 1,387,800
5/8/2018 39.770 41.540 39.070 40.525 5,628,500
5/7/2018 44.140 44.790 43.600 44.330 1,460,700
5/4/2018 41.830 44.670 41.250 44.010 2,031,600
5/3/2018 42.650 42.910 41.060 41.270 1,266,600
5/2/2018 42.470 43.670 42.470 42.740 1,439,500
5/1/2018 42.870 44.130 42.030 42.630 1,208,500
4/30/2018 45.300 45.300 43.000 43.030 1,593,100
4/27/2018 43.710 45.230 43.620 45.060 1,042,400
4/26/2018 44.130 44.490 43.180 43.480 1,135,900
4/25/2018 45.560 45.950 43.950 43.980 1,024,500
4/24/2018 49.410 49.750 44.810 45.330 3,218,800
4/23/2018 48.850 51.000 48.740 50.700 2,625,200
4/20/2018 50.440 50.440 46.770 48.510 4,732,500
4/19/2018 46.040 46.555 44.930 45.850 1,379,100
4/18/2018 44.490 47.085 44.490 46.030 1,405,700
4/17/2018 43.790 44.790 43.610 44.490 620,000
4/16/2018 43.690 43.870 43.080 43.470 538,000
4/13/2018 43.950 43.950 42.690 43.620 524,900
4/12/2018 43.650 44.310 43.110 43.820 964,900
4/11/2018 43.360 44.340 43.070 43.550 1,322,000
4/10/2018 42.120 43.680 41.915 43.600 1,197,300
4/9/2018 41.020 42.630 40.845 41.610 973,500
4/6/2018 42.160 42.230 40.330 40.680 978,700
4/5/2018 43.370 43.710 42.480 42.540 771,300
4/4/2018 41.260 43.200 40.700 43.000 1,098,600
4/3/2018 42.270 43.090 41.640 42.000 1,148,300
4/2/2018 44.000 44.080 41.130 42.120 1,586,300
3/29/2018 46.150 46.690 43.380 44.080 2,397,800
3/28/2018 45.770 46.910 45.210 45.930 1,254,000
3/27/2018 49.400 49.490 45.560 45.800 1,556,400
3/26/2018 48.380 49.500 47.370 48.990 1,555,200
3/23/2018 50.690 50.780 47.550 47.740 1,015,000
3/22/2018 51.370 52.270 50.710 50.780 760,000
3/21/2018 51.060 52.080 51.030 51.900 527,700
3/20/2018 52.500 52.820 50.610 51.120 635,300
3/19/2018 51.560 53.150 51.250 52.610 973,800
3/16/2018 52.270 52.270 51.270 51.690 876,900
3/15/2018 52.500 52.630 49.690 52.180 2,059,400
3/14/2018 55.290 55.710 52.950 53.570 725,400
3/13/2018 55.130 56.470 54.800 55.050 1,271,700
3/12/2018 53.180 55.170 53.050 54.780 1,081,200
3/9/2018 52.720 53.415 52.100 52.980 771,000
3/8/2018 53.390 53.560 52.010 52.280 629,500
3/7/2018 51.110 53.620 50.600 53.310 1,366,200
3/6/2018 50.430 51.890 49.775 51.630 1,153,700
3/5/2018 48.890 50.730 48.880 49.930 1,070,300
3/2/2018 50.740 51.000 47.195 48.940 1,677,800
3/1/2018 52.940 53.220 48.910 49.890 1,818,400


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